Strontium-82 Separation

⁸²Rb is an emerging PET isotope for the diagnosis of cardiovascular disease. The short-lived ⁸²Rb (t1/2 = 1.2575 minutes) is directly injected from a generator containing ⁸²Sr immobilized on a column of hydrous stannic oxide. ⁸²Sr itself, is produced by proton irradiation of natural Rb targets. Following dissolution of the irradiated Rb target (up to 50 grams) in HNO₃, the separation of ⁸²Sr is achieved using a column of Sr Resin. After recovering the ⁸²Sr in 0.05-0.20M HNO₃, a small column of strong acid cation exchange resin is used to concentrate the Sr and remove any 1-octanol or crown ether that may have leached from the Sr Resin.[1]

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References:

[1] Dunin, A.V., Nerozin, N.A., Togaeva, N.R., Khamyanov, S.V., Shapovalov, V.V. 2014. Extraction of Sr-82, Raw Material for Radiopharmaceutical Production. Pharmaceutical Chemistry Journal, 48(6), 395-397.